Endocrine Abstracts

Papillary thyroid carcinoma (PTC) is a malignant tumour of follicular cell origin that is characterized by a broad diversity of histological variants. A genesis of multifocal PTC may be explained by both intrathyroid tumour dissemination and multiple focuses of tumour origination. A combination of two different focuses of PTC characterized by various molecular alterations of tumour cells in one thyroid could be rarely occurred. Follicular variant has similar clinical behaviour...

Background: Papillary thyroid carcinoma (PTC), the most common endocrine malignancy, is a tumor of indolent biological and clinical behaviour that usually has a good prognosis. Only a small percentage of patients are affected by aggressive variants of PTC: tall, columnar cell and diffuse sclerosing variants. These aggressive tumor subtypes are characterized by higher rate of local recurrence, regional and distant metastases than classic papillary PTC. Recently another clinical...

Background: Papillary thyroid carcinoma (PTC), especially its classic papillary, oncocytic, Warthin-like, tall and columnar cell variants, is characterized by a high frequency of BRAFV600E mutation that varies in different studies from 36 to 85%. Prognostic significance of the mutation remains controversial.Objective: Aim of the study was an analysis of relationship between clinical, morphological and prognostic characteristics of PTC with BRAFV600E asse...